the potential of honey to promote wound healing in periodontology: a pilot randomized clinical trial

نویسندگان

mahmood khosravi samani dentistry school, dental material research center, babol university of medicalsciences, babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)سازمان های دیگر: dental material research center

arash poorsattar bejeh mir babol university of medical sciences,babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)

gholamali mohammadnejad department of periodontology, dentistry school, dental material research center, babol university of medical sciences, babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)سازمان های دیگر: dental material research center

behrooz sajadi honey bee group, mazandaran university, babolsar, iran.سازمان اصلی تایید شده: دانشگاه مازندران (mazandaran university)

چکیده

abstract background & objectives: honey has been used as a nutraceutical in many traditional and ancient remedies. considering well documented benefits of honey to accelerate wound healing, for the first time we aimed to assess intra oral surgical wound healing process with honey. methods: we designed a pilot randomized placebo controlled cross-over clinical trial. patients who required bilateral modified widman flap (mwf) surgery randomly assigned to receive either 15 cc topical persian thymus vulgaris concentrated honey three times a day or normal saline as placebo with the same amount at the site of the surgery for seven consecutive days. after a 35-day wash-out period the study groups were crossed. the primary efficacy outcome was changes in healing index (landry index) and the secondary efficacy outcome were changes in gingival and plaque indices (loe & sillness, sillness & loe indices). it also includes safety issues consisting of any allergic reaction, delayed healing or wound dehiscence. results: ten patients enrolled with the mean age of 36 (±1.5) ranged between 35-40 yrs. there was a significant improvement in wound healing considering time and treatment effects in both groups, although faster wound healing observed in honey treated patients (p< 0.001). in both groups gingival indices were noticed to be improved by the time during the first phase of the study. both groups displayed aggravated plaque formation nevertheless it was merely statistically significant in the control group [f (3, 27) =12.88, p value < 0.001]. all wounds healed normally and no adverse events recorded. conclusion: our study established the safety, efficacy and feasibility of topical honey to promote periodontal surgical wound healing. (irct138901192547n2)

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The potential of honey to promote wound healing in periodontology: a pilot randomized clinical trial

 Abstract Background & Objectives: Honey has been used as a nutraceutical in many traditional and ancient remedies. Considering well documented benefits of honey to accelerate wound healing, for the first time we aimed to assess intra oral surgical wound healing process with honey. Methods: We designed a pilot randomized placebo controlled cross-over clinical trial. Patients who required bilate...

متن کامل

Wound healing activity of honey: A pilot study

Vrana (wound) and its sequels play a major concern in the field of surgery as Vrana Ropana (wound healing) requires uneventful healing. The aim of the study was to evaluate the changes in physical and morphological properties due to topical application of Madhu (honey) on fresh traumatic wounds or cutaneous wounds. Ten patients of wounds of either sex were randomly selected. Site of the wound, ...

متن کامل

The effect of honey gel on abdominal wound healing in cesarean section: a triple blind randomized clinical trial.

OBJECTIVE To assess whether honey can accelerate the wound healing in women undergoing cesarean section. METHODS This was a triple blinded randomized prospective clinical trial. Women with cesarean section were randomly designated as drug (37 cases) and placebo (38 cases) groups. The drug group received local honey gel 25% while the placebo group received similar free-honey gel on abdominal c...

متن کامل

A Small Peptide with Potential Ability to Promote Wound Healing

Wound-healing represents a major health burden, such as diabetes-induced skin ulcers and burning. Many works are being tried to find ideal clinical wound-healing biomaterials. Especially, small molecules with low cost and function to promote production of endogenous wound healing agents (i.e. transforming growth factor beta, TGF-β) are excellent candidates. In this study, a small peptide (tiger...

متن کامل

Wound healing with honey--a randomised controlled trial.

OBJECTIVES To compare honey and IntraSite Gel as woundhealing agents, to record side-effects, gauge patient satisfaction and calculate the cost-effectiveness of the honey used. DESIGN AND SETTING A prospective, randomised, double-blind controlled trial was carried out among goldmine workers. OUTCOME MEASURES Outcome measures were healing times of shallow wounds and abrasions; side-effects; ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۲۵، شماره ۴، صفحات ۱۷۷-۱۸۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023